Unique GITS technology

Adalat GITS uses a specific osmotic ‘push-pull’ delivery system

The Adalat GITS bilayer tablet comprises:
  • A polymeric “push compartment” layer (insoluble in water)
  • A drug reservoir layer
  • A semi-permeable outer membrane with a single precision laser-drilled hole on the drug-reservoir side1
Once the tablet is swallowed, water penetrates the semi-permeable coating1. The osmotically active layer swells up, forcing nifedipine out of the delivery orifice1. The nifedipine is administered evenly over a 24-hour period1.
Adalat GITS is a specific technology not available in most generic nifedipine formulations2.

References

  1. Grundy JS, et al. Clin Pharmacokinet. 1996;30:28-51.
  2. Meredith PA, et al. Integr Blood Press Control. 2013;6:79-87.

Homepage references

  1. Grundy JS, et al. Clin Pharmacokinet 1996;30:28-51.
  2. Toal CB, et al. Int J Clin Pharmacol Ther 2012;50:202-17.
  3. Meredith PA, et al. J Hypertens 2004;22:1641-8.
  4. Schug BS, et al. Eur J Clin Pharmacol 2002;58:119-25.
  5. Anschutz M, et al. Int J Clin Pharmacol Ther 2010;48:158-70.
  6. Toal CB, et al. Blood Press. 2012;21 Suppl 1:3-10.