Distinct PK/PD profile
Differences in pharmacology distinguish Adalat GITS from generic nifedipine
The rate and extent of release of Adalat GITS remains consistent throughout the physiological range of pH values1.
At 24 hours, complete or near-complete release is achieved at all pH levels from 1 (0.1 M hydrochloric acid) to 8 (phosphate buffer)1.
The release of Adalat GITS is also unaffected by changes in other test conditions, including agitation, osmolarity and the presence of surfactants1.
- Shorter lag time, i.e. earlier onset of release2
- Higher terminal release, i.e. more drug released by the end of the 24-hour period2
- Schug BS, et al. Eur J Clin Pharmacol (2002) 58: 119-125.
- Anschutz M, et al. Int J Clin Pharmacol Ther 2010;48:158-70.