Product Characteristics

Adalat GITS

Adalat (nifedipine) is a dihydropyridine (DHP) calcium channel blocker (CCB) indicated for the treatment of hypertension and for the treatment of chronic stable angina pectoris.1 The Adalat Gastrointestinal Therapeutic System (GITS) is a technology that allows nifedipine a sustained release over a 24 hour period.2,3 The antihypertensive efficacy and safety profile of the Adalat GITS formulation have been demonstrated in large-scale, randomised, clinical trials.4-6

  • Adalat GITS Mode of Action

    Follow the GITS tablet while it passes through the gastrointestinal tract.

  • Expert opinion on Adalat GITS

    Dr. Corey Toal describes the specific delivery system of Adalat GITS.

  • Adalat Production Video

    Check out how the GITS tablets are produced in compliance with the most stringent quality and manufacturing requirements.


Adalat GITS...

BP lowering

Adalat GITS provides effective and sustained BP lowering5

  • The INSIGHT study recorded blood pressure in patients (n=6321) with hypertension who were treated with co-amilozide or Adalat*5
  • 58% of patients treated with Adalat achieved the guideline-recommended BP target of 140/90 mmHg5
  • 69% of patients remained on Adalat monotherapy after 48 months5
*The primary outcome of INSIGHT was cardiovascular death, myocardial infarction, heart failure, or stroke.

Specific delivery system

Adalat GITS uses a specific osmotic ‘push-pull’ delivery system

The Adalat GITS tablet comprises a layer of nifedipine and a layer of osmotically active granules, with a semi-permeable, non-water-soluble outer coating.2 A small hole is drilled through the outer coating.2

After administration, the tablet absorbs water to create a nifedipine suspension in the drug reservoir.2 As the polymer expands and the osmotic pressure increases, the drug suspension is extruded through the precision-drilled pore at a controlled rate over 24 hours.2

Adalat GITS is a specific technology not available with generic nifedipine formulations.

Generic extended release nifedipine

Improved performance

Adalat GITS: improved performance compared to previous Adalat formulations

Constant dissolution: schematic figure

24-hour drug availability7


  1. Adalat Health Care Professional Information.
  2. Grundy JS, et al. Clin Pharmacokinet. 1996;30:28-51.
  3. Meredith PA, et al. Integr Blood Press Control. 2013;6:79-87.
  4. Mancia G, et al. J Hypertens 2002;20:545-53.
  5. Brown M, et al. Lancet 2000;356:366-72.
  6. Mancia G, et al. Hypertension 2003;41:431-6.
  7. Meredith PA, et al. J Hypertens. 2004;22:1641-8.