• New Guidelines

    New ‘Guidelines for the management of arterial hypertension’ have been published by ESC / ESH earlier 2018.

  • Hypertension is a global problem

    The incidence of high blood pressure is increasing worldwide, particularly in Asia.1 Raised blood pressure predicts an increased risk of CVD.2

  • Sustained long-term BP control

    Adalat GITS provides sustained long-term BP control in a wide range of patients, including those with additional cardiovascular risk factors.3-7 Adalat GITS has been demonstrated efficacy in monotherapy4 and combination therapy,8-11 and has a well-established safety profile.12

  • Preferred partner for combination therapy

    Most patients require combination therapy to reach target blood pressure.13,14 Adalat GITS, as a calcium channel blocker, is a preferred combination partner for ACE inhibitors and ARBs (renin-angiotensin targeting drugs), due to its complementary mechanism of action.8-11,15-17

  • Favourable PK/PD profile

    The unique osmotic ‘push-pull’ delivery system of Adalat GITS allows controlled, consistent drug release over 24 hours with once-daily dosing.18-20 Adalat GITS has a superior pharmacokinetic profile compared to generic nifedipine formulations.19-22 In addition, Adalat GITS has a low degree of sympathetic nervous system activation with minimal effects on heart rate while showing similar BP reductions compared to amplodipine.23

Guideline recommendations for CCBs

Dihydropyridine CCBs are a recommended therapeutic option in the ESH/ESC 2013 guideline on hypertension, and are further identified as the only drug class with no compelling contraindication to use.13 Recommendations for CCBs are found in many other national hypertension guidelines, including those for the USA, Canada, China, Korea and Taiwan.24-29



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  4. Brown M, et al. Lancet 2000;356:366-72.
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  6. Bravo EL, et al. Am J Hypertens 1990;3:326S-32S.
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  12. Adalat Health Care Professional Information.
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  15. Haller H. Int J Clin Pract 2008;62:781–90.
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  25. Flack JM, et al. Hypertension 2010;56:780-800. Available at: http://goo.gl/o85pwp. Accessed 10 October 2017.
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  27. Liu LS, et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39:579-615.
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